Early NFL Week 2 lines put Bills ahead of Lions

Fox Sports has released early betting lines for all 16 2026 NFL Week 2 games, with the Detroit Lions’ visit to the Buffalo Bills highlighted as the Thursday night matchup.

Bet365 lists Buffalo as a 4.5-point favourite against Detroit, with the Lions–Bills game carrying the highest total among the quoted markets at 53.5 points.

Other prominent lines include San Francisco at -12.5 against Miami and Kansas City at -6.5 against Indianapolis. The Eagles are listed at -7 against Tennessee, while the Ravens and Buccaneers are each favoured by 8.5 points against New Orleans and Cleveland respectively.

The lowest listed total is 39.5 for Philadelphia’s game against the Titans. Across the full schedule, the quoted totals range from 39.5 to 53.5 points.

The prices were published on 14 September and are described as early lines, meaning they may change. They are bookmaker markets rather than confirmed results or guaranteed predictions.

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