CBS Sports Week 4 picks put 49ers and Colts in focus
CBS Sports and SportsLine published odds and expert predictions across the NFL slate, including San Francisco’s matchup with Denver and Indianapolis’s game in London.
CBS Sports and SportsLine have compiled opening odds, expert picks and betting analysis for NFL Week 4. The preview covers the full slate, with selected matchups including Colts–Commanders in London and 49ers–Broncos.
Washington opened as a 1.5-point favourite against Indianapolis, with the total set at 48.5. CBS Sports’ Pete Prisco predicted a 31–30 Colts win, citing improved defence and expecting both teams to score freely.
San Francisco opened as a 2.5-point favourite over Denver, with the total at 46.5. CBS Sports’ Jared Dubin picked the 49ers to win and reach 4-0, pointing to the team’s offensive form through the first three weeks.
Other picks in the preview include the Bengals over the Jaguars, Cardinals over the Giants, Rams over the Eagles and Cowboys over the Texans. Tyler Sullivan backed Minnesota to cover the 7.5-point spread against Miami.
The material brings together predictions and betting advice, including selections from CBS Sports contributors and SportsLine experts. The listed odds are opening lines; the predictions are opinions, not game results.
