Bills favoured as Lions visit Buffalo for Week 2 Thursday night
Buffalo is listed as a 4.5-point favourite against Detroit, while SportsLine’s model projects 58 total points.
The Detroit Lions are scheduled to face the Buffalo Bills at Highmark Stadium in the opening game of Week 2 of the 2026 NFL season. Kick-off is listed for 8:15 p.m. ET.
Buffalo enters the matchup after a reported 36-31 win over Houston in Week 1. Detroit also began the season with a victory, defeating New Orleans 31-30 in overtime.
CBS Sports lists Buffalo as a 4.5-point favourite, with the total set at 54.5 points. The fixture date was not provided in the supplied material.
SportsLine’s model projects 58 combined points and gives the Over 54.5 a reported 57 per cent probability across 10,000 simulations. The projection is attributed to the model and is not a confirmed result.
The supplied preview cites offensive performances from both teams, including Detroit running back Jahmyr Gibbs and quarterback Jared Goff, alongside Buffalo quarterback Josh Allen and tight end Dalton Kincaid.
Buffalo reportedly finished 12-5 in 2025, while Detroit finished 9-8. The source does not state which team SportsLine favours against the spread.
