Event
Ole Miss and Louisville will open their 2026 college football seasons at Nissan Stadium in Nashville, with kickoff scheduled for 7:30 p.m. ET. Ole Miss is a 6.5-point favourite, with an over/under of 55.5 points.
2 published stories · college-football · source reliability 33%
No. 9 Ole Miss will meet No. 24 Louisville at Nissan Stadium, with the Rebels entering as a 6.5-point favourite in the latest figures cited by CBS Sports.
Background
No. 9 Ole Miss will open the 2026 college football season against No. 24 Louisville at Nissan Stadium in Nashville. Ole Miss reached last season’s College Football Playoff semi-finals and retains quarterback Trinidad Chambliss and leading rusher Kewan Lacy. Louisville went 9–4 under Jeff Brohm and retains leading rusher Isaac Brown; Ohio State transfer Lincoln Kienholz is expected to start at quarterback.
No. 9 Ole Miss will open the 2026 college football season against No. 24 Louisville at Nissan Stadium in Nashville. Ole Miss reached last season’s College Football Playoff semi-finals and retains quarterback Trinidad Chambliss and leading rusher Kewan Lacy. Louisville went 9–4 un
Fact cards
Key entities: Ole Miss Rebels, Louisville Cardinals, Nissan Stadium, SportsLine.
When and where is the game? At Nissan Stadium in Nashville; kick-off is scheduled for 7.30pm ET. Which teams are playing? No. 9 Ole Miss and No. 24 Louisville. What are the latest cited odds? Ole Miss is a 6.5-point favourite; the over/under is 55.5 points. Who are the key player
CBS Sports | https://www.cbssports.com/betting/news/louisville-vs-ole-miss-betting-odds-picks-predictions-time-for-college-football-week-1 | published 2026-09-06T15:30:48.000Z | primary source | CBS Sports | Primary preview, team details, schedule information and cited betting li
Last season: Ole Miss reached the College Football Playoff semi-finals after Lane Kiffin moved to LSU before the play-offs. Last season: Louisville finished 9–4 under Jeff Brohm. 2026 season opener: Ole Miss and Louisville are scheduled to meet at Nissan Stadium in Nashville, wit
Timeline
Ole Miss reached the College Football Playoff semi-finals after Lane Kiffin moved to LSU before the play-offs.
Louisville finished 9–4 under Jeff Brohm.
Ole Miss and Louisville are scheduled to meet at Nissan Stadium in Nashville, with kick-off at 7.30pm ET.
CBS Sports published the cited preview and latest betting figures.
FAQ
At Nissan Stadium in Nashville; kick-off is scheduled for 7.30pm ET.
No. 9 Ole Miss and No. 24 Louisville.
Ole Miss is a 6.5-point favourite; the over/under is 55.5 points.
Ole Miss quarterback Trinidad Chambliss and rusher Kewan Lacy; Louisville quarterback Lincoln Kienholz and rusher Isaac Brown.
Ole Miss is a 6.5-point favourite and the total is 54.5 points.
It predicts the game will finish under 54.5 points, with a projected combined score of 49.
It reached the College Football Playoff last season and is beginning a new era under Pete Golding.
It has won at least nine games in each of his three seasons.